View abstract. Clin J Pain 2002;18:200-2. J Dermatol Treat 1990;1(5):235-238. 2020;24(2):160-164. View abstract. Taylor B, Luscombe D, and Duthie H. Inhibitory effect of peppermint oil on gastrointestinal smooth muscle. Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J., Gavaghan, D. J., and McQuay, H. J. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Spasmolytic effect of peppermint oil in barium during double-contrast barium enema compared with Buscopan. View abstract. Iscan G, Kirimer N, Kurkcuoglu M, et al. A literature survey. Dig Liver Dis 2007;39:530-6. View abstract. Some medications that decrease stomach acid include cimetidine (Tagamet), ranitidine (Zantac), nizatidine (Axid), and famotidine (Pepcid). Studies are showing the positive effects of peppermint oil application to patients suffering from migraines; it reduces the severity of the pain within 15minutes of application. Pharmacol Biochem.Behav. View abstract. Postgrad Med J 1987;63:717. Cyclosporine (Neoral, Sandimmune) interacts with PEPPERMINT. View abstract. Early research shows that inhaling peppermint oil slightly improves memory and performance on mental tasks, but does not improve attention and speed of completing tasks. View abstract. 2007;100(4):249-257. View abstract. View abstract. View abstract. Ebbinghaus K D. A 'tea' containing various plant products as adjuvant to chemotherapy of urinary tract infections. 2014 Feb;29(1):12-9. doi: 10.1016/j.jopan.2013.09.008. 2005;12(8):607-611. Davies SJ, Harding LM, Baranowski AP. Haeseler, G., Maue, D., Grosskreutz, J., Bufler, J., Nentwig, B., Piepenbrock, S., Dengler, R., and Leuwer, M. Voltage-dependent block of neuronal and skeletal muscle sodium channels by thymol and menthol. 13 Surprising Health Benefits of Rose Essential Oil, 13 Surprising Benefits of Fennel Essential Oil, 11 Incredible Health Benefits of Sesame Oil, 13 Incredible Health Benefits of Thyme Essential Oil, 11 Surprising Benefits of Sage Essential Oil, 13 Amazing Benefits of Lemongrass Essential Oil, 11 Health Benefits of Sandalwood Essential Oil, 13 Amazing Benefits of Rosemary Essential Oil, 11 Impressive Health Benefits of Figs (Anjeer). BMJ 2008;337:a2313. Feng, X. Hepato-Gastroenterology 1980;27(Suppl):252. Am J Dent 2000;13(Spec No):26C-30C. Biofactors 2004;21(1-4):137-139. Some medications are changed and broken down by the liver. Arzneimittelforschung 2001;51(6):465-469. Indian J Exp Biol. A combination of peppermint oil and caraway oil for the treatment of functional dyspepsia: A systematic review and meta-analysis. Peppermint oil in enteric coated capsules for the treatment of irritable bowel syndrome: a double blind controlled trial. Adam, B., Liebregts, T., Best, J., Bechmann, L., Lackner, C., Neumann, J., Koehler, S., and Holtmann, G. A combination of peppermint oil and caraway oil attenuates the post-inflammatory visceral hyperalgesia in a rat model. Brandi has a Bachelor's in Journalism from the Georgia Perimeter College. Sullivan, T. E., Warm, J. S., Schefft, B. K., Dember, W. N., O'Dell, M. W., and Peterson, S. J. Phytother Res 2000;14:20-3. Cohen, B. M. and Dressler, W. E. Acute aromatics inhalation modifies the airways. View abstract. leaf extract provides protection against radiation induced chromosomal damage in bone marrow of mice. Kalavala, M., Hughes, T. M., Goodwin, R. G., Anstey, A. V., and Stone, N. M. Allergic contact dermatitis to peppermint foot spray. 2010;50(1):30-35. Naito, K., Ohoka, E., Kato, R., Kondo, Y., and Iwata, S. The effect of L-menthol stimulation of the major palatine nerve on nasal patency. Suares, N. C. and Ford, A. C. Diagnosis and treatment of irritable bowel syndrome. 2002;40(11):1245-1249. View abstract. Mutluay Yayla E, Izgu N, Ozdemir L, Aslan Erdem S, Kartal M. Sage tea-thyme-peppermint hydrosol oral rinse reduces chemotherapy-induced oral mucositis: A randomized controlled pilot study. Respiration 1982;43(4):285-293. View abstract. Response of irritable bowel syndrome with constipation patients administered a combined quebracho/conker tree/M. Gastroenterology 1991;101(1):55-65. 2006;82(5):331-337. Bayat R, Borici-Mazi R. A case of anaphylaxis to peppermint. What factors influenced or will influence your purchase? View abstract. Umezu, T. and Morita, M. Evidence for the involvement of dopamine in ambulation promoted by menthol in mice. Some medications that decrease stomach acid might cause the coating of these peppermint oil products to dissolve too quickly. Katikova, O. I., Kostin, IaV, and Tishkin, V. S. [Hepatoprotective effect of plant preparations]. Rogers SN, Pahor AL. Mascher, H., Kikuta, C., and Schiel, H. Pharmacokinetics of menthol and carvone after administration of an enteric coated formulation containing peppermint oil and caraway oil. Kligler B, Chaudhary S. Peppermint oil. Satsu, H., Matsuda, T., Toshimitsu, T., Mori, A., Mae, T., Tsukagawa, M., Kitahara, M., and Shimizu, M. Regulation of interleukin-8 secretion in human intestinal epithelial Caco-2 cells by alpha-humulene. View abstract. Rees WD, Evans BK, Rhodes J. 2005;133(5):801-802. Early research shows that rinsing with a solution containing peppermint powder and other ingredients reduces plaque compared to a water solution. Peppermint oil solution is useful as an antispasmodic drug for esophagogastroduodenoscopy, especially for elderly patients. Storr M, Sibaev A, Weiser D, et al. Gut 1999;45 Suppl 2:II69-II77. View abstract. Peppermint liquid castile body wash made from high grade vegetable oil & pure peppermint essential oil. Acute lung injury after peppermint oil injection. Eccles, R., Griffiths, D. H., Newton, C. G., and Tolley, N. S. The effects of D and L isomers of menthol upon nasal sensation of airflow. Ann.Pharm Fr. Most research shows that taking peppermint oil by mouth reduces stomach pain, bloating, gas, and bowel movements in people with IBS. Ugeskr.Laeger 10-3-1988;150(40):2388-2389. View abstract. Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast). View abstract. View abstract. Enck, P., Junne, F., Klosterhalfen, S., Zipfel, S., and Martens, U. View abstract. Probl Tuberk 2002;(4):36-39. Dig.Dis.Sci. Samarth, R. M., Panwar, M., and Kumar, A. Modulatory effects of Mentha piperita on lung tumor incidence, genotoxicity, and oxidative stress in benzo[a]pyrene-treated Swiss albino mice. Merat, S., Khalili, S., Mostajabi, P., Ghorbani, A., Ansari, R., and Malekzadeh, R. The effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndrome. 1997;32(10):577-578. View abstract. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. WebMD does not provide medical advice, diagnosis or treatment. Exp Parasitol. Peppermint oil is an ingredient in many skin care products and medicine. View abstract. View abstract. Mimica-Dukic, N., Bozin, B., Sokovic, M., Mihajlovic, B., and Matavulj, M. Antimicrobial and antioxidant activities of three Mentha species essential oils. View abstract. Hiki, N., Kurosaka, H., Tatsutomi, Y., Shimoyama, S., Tsuji, E., Kojima, J., Shimizu, N., Ono, H., Hirooka, T., Noguchi, C., Mafune, K., and Kaminishi, M. Peppermint oil reduces gastric spasm during upper endoscopy: a randomized, double-blind, double-dummy controlled trial. Eating peppermint tea or adding it to a bath may help in bringing down fever gently without medicine and any adverse effect on the body’s ability to fight illness. Barnick CG and Cardozo LD. 2005;12(8):612-616. View abstract. Complement Ther Med 2016;27:58-64. Shin BC, Lee MS. An analysis using patch clamp electrophysiology and isolated tissue pharmacology in rabbit and guinea pig. 2009;91(3):315-320. 2007;75(7):1027-30. View abstract. Hitz, Lindenmuller, I and Lambrecht, J. T. Oral care. Take medications that decrease stomach acid at least two hours after coated peppermint oil products Am J Respir Crit Care Med 1997;156(1):309-313. Lazutka, J. R., Mierauskiene, J., Slapsyte, G., and Dedonyte, V. Genotoxicity of dill (Anethum graveolens L.), peppermint (Menthaxpiperita L.) and pine (Pinus sylvestris L.) essential oils in human lymphocytes and Drosophila melanogaster. Determination of menthol and menthol glucuronide in human urine by gas chromatography using an enzyme-sensitive internal standard and flame ionization detection. Arch.Pharm Res 2005;28(7):770-774. Anderson LA, Gross JB. View abstract. Peppermint oil has many beneficial uses, like relieving GI discomfort, easing nausea, and alleviating pain. Br Med J 1979;2:835-6. Iran J Pharm Res. The extraction of peppermint essential oil is done through the process of steam distillation. Shavakhi, A., Ardestani, S. K., Taki, M., Goli, M., and Keshteli, A. H. Premedication with peppermint oil capsules in colonoscopy: a double blind placebo-controlled randomized trial study. The anti-spasmodic effect of peppermint oil during colonoscopy: a systematic review and meta-analysis. Gobel H, Fresenius J, Heinze A, et al. Pak.J Biol.Sci. View abstract. View abstract. Umezu, T. Evidence for dopamine involvement in ambulation promoted by menthone in mice. The body breaks down cyclosporine (Neoral, Sandimmune) to get rid of it. Samarth, R. M., Saini, M. R., Maharwal, J., Dhaka, A., and Kumar, A. Mentha piperita (Linn) leaf extract provides protection against radiation induced alterations in intestinal mucosa of Swiss albino mice. Br J Nutr 1999;81:289-95. View abstract. 2007;115(1):25-31. Phytother.Res 2003;17(2):135-140. Gyogyszereszet 1990;34(251):253. Effects of intraduodenal application of peppermint oil (WS(R) 1340) and caraway oil (WS(R) 1520) on gastroduodenal motility in healthy volunteers. Lis-Balchin, M., Steyrl, H., and Krenn, E. The comparative effect of novel Pelargonium essential oils and their corresponding hydrosols as antimicrobial agents in a model food system. Aliment Pharmacol Ther 2004;20:1279-87. Some medications that are changed by the liver include omeprazole (Prilosec), lansoprazole (Prevacid), and pantoprazole (Protonix); diazepam (Valium); carisoprodol (Soma); nelfinavir (Viracept); and others. Am Fam.Physician 9-1-2012;86(5):419-426. 2009;48(4):440-446. 2008;22(4):402-405. Eur J Anaesthesiol. Indigestion (dyspepsia). Improved performance on clerical tasks associated with administration of peppermint odor. Anesth Analg 2013;117(3):597-604. Peppermint oil is an excellent tonic that enhances appetite and also reduces the accumulation of gas in the intestinal cavity. Clin J Pain 2002;18(3):200-202.